Lodovico Guicciardini (19 August 1521 – 22 March 1589) was an Italian writer and merchant from Florence, but who lived primarily in Antwerp. He was the nephew of historian and diplomat Francesco Guicciardini.
His best-known work, the Descrittione di Lodovico Guicciardini patritio fiorentino di tutti i Paesi Bassi altrimenti detti Germania inferiore (1567; The Description of the Low Countreys) was an influential account of the history and the arts of the Low Countries, accompanied by city maps by various leading engravers.
Guicciardini died in Antwerp in 1589. He was buried in the Cathedral of Our Lady (Onze-Lieve-Vrouwekathedraal) in the city.